The anticoagulant activity of 1-MNA has also been shown in studies focusing on the level of 6-keto-PGF1α (stable PGI2 metabolite) and thromboxane B2 (TXB2) in arterial blood. These studies show that the anticoagulant response to 1-MNA correlates with the concentration of 6-keto-PGF1α, reflecting the level of PGI2 being released into the bloodstream. The concentration of TXB2 increased over time, but only to a slight degree (Diagram C).
Diagram C. The influence of 1-MNA on the release of PGl2. The level of 6-keto-PGF1α and other prostanoids measured after administering 1-MNA (30 mg/kg). (Chlopicki et al., 2007– Literature >>).