The influence of 1-MNA on survival rate

Studies conducted in renowned research centres (including Swiss Federal Institute of Technology (ETH) Zurich, Switzerland and Harvard Medical School, Boston, USA) and published in Nature Chemical Biology (Schmeisser et al., 2013 – Literature  >>) demonstrate that 1-MNA positively affects life expectancy in a commonly used nematode biological ageing model (Caenorhabditis elegans).

The experiments demonstrated that sirtuins (Sirt1) contribute to prolonging life expectancy of C. elegans through increased formation of  the pro-oxidative substrate, 1-MNA. Impaired amine N-methyltransferase (ANMT-1) function confirms that 1-MNA is of crucial significance as far as the regulation of life expectancy of these nematodes (Diagram A). 

Diagram A. The influence of 1-MNA on the life expectancy of nematodes ANMT-1(gk457) (Schmeisser et al., 2013 – Literature  >>).

The authors of the study state that the crucial role attributed to sirtuins (proteins, most probably related with the ageing process) results from their participation in the metabolic pathway of the nicotinic acid, where 1-MNA originates (Diagram B). The authors also suggest that supplementation of 1-MNA may pose a beneficial influence on the health and life expectancy of humans.

Diagram B. The role of sirtuins in the metabolism of 1-MNA (Schmeisser et al., 2013Literature  >>).

Studies published in Nature Medicine (Hong et al., 2015 – Literature  >>) also demonstrated the relationship between sirtuin 1 (Sirt1) and 1-MNA (Hong et al., 2015 – Literature  >>). These studies demonstrate that 1-MNA increases the expression of Sirt1 and also positively influences their stabilisation (Diagram C).

Diagram C. The influence 1-MNA on the expression of Sirt1 protein in animals receiving a high fat diet (HFD) (Hong et al., 2015Literature  >>).

According to in vivo studies, supplementation of 1-MNA to the high-fat diet of laboratory animals prevented metabolic deregulation. 1-MNA increased the level of Sirt1 in the liver, inhibited the synthesis of cholesterol and fatty acids in hepatocytes, reduced the level of triglycerides and the cholesterol content in the liver, as well as limited hepatitis (Hong et al., 2015 – Literature  >>).