The influence of 1-MNA on survival rate
Studies conducted in renowned research centres (including Swiss Federal Institute of Technology (ETH) Zurich, Switzerland and Harvard Medical School, Boston, USA) and published in Nature Chemical Biology (Schmeisser et al., 2013 – Literature >>) demonstrate that 1-MNA positively affects life expectancy in a commonly used nematode biological ageing model (Caenorhabditis elegans).
The experiments demonstrated that sirtuins (Sirt1) contribute to prolonging life expectancy of C. elegans through increased formation of the pro-oxidative substrate, 1-MNA. Impaired amine N-methyltransferase (ANMT-1) function confirms that 1-MNA is of crucial significance as far as the regulation of life expectancy of these nematodes (Diagram A).