The influence of 1-MNA on the vascular endothelium

Vascular endothelial dysfunction associated with lowered nitric oxide (NO) bioavailability inside vessels is an early and common mechanism leading to damage of blood vessels and as a consequence is a predisposition to cardiovascular incidents. Recent studies show that 1-MNA increases the bioavailability of NO in the vascular endothelium and hence regulates the impaired activity of endothelial nitric oxide synthase.

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1-MNA anticoagulant activity and the release of prostacyclin (PGI2)

In vivo studies demonstrate the anticoagulant activity of 1-MNA (Chlopicki et al., 2007– Literature  >>). During these studies, 1-MNA resulted in dose-dependent thrombolysis which was maintained over time (anticoagulant effect).

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1-MNA anti-inflammatory activity

In a study of dyslipidemic patients, 1-MNA decreased the blood level of high sensitivity C-reactive protein (hsCRP) by 17%, and reduced the blood level of tumour necrosis factor (TNF-α) by 14%. In patients with the highest initial level of TNF-α, 1-MNA reduced its level by 29%. hsCRP and TNF-α are inflammatory markers that play a crucial role in the course and the development of various cardiovascular events, as well as in treating inflammatory diseases. This study was conducted through the renowned Montreal Heart institute in Canada.

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The influence 1-MNA on survival rate

Studies conducted in renowned research centres (including Swiss Federal Institute of Technology (ETH) Zurich, Switzerland and Harvard Medical School, Boston, USA) and published in Nature Chemical Biology (Schmeisser et al., 2013 – Literature  >>) demonstrate that 1-MNA positively affects life expectancy in a commonly used nematode biological ageing model (Caenorhabditis elegans). 

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